Endocrine Abstracts

Background: Primary hyperparathyroidism is a common endocrine disorder characterized by hypercalcemia, resulting from excessive secretion of parathyroid hormone. Parathyroidectomy, is considered as the definitive treatment for this condition, leading in most cases to remission and resolution of hypercalcemia. However, some patients experience surgical failure. Persistent hyperparathyroidism is defined as persistence of hypercalcemia after parathyroidectomy or recurrence of hyp...

Background: Primary hyperparathyroidism, is defined by hypercalcemia associated with an elevated or inappropriately normal parathyroid hormone(PTH) levels stemming from hyperfunctioning parathyroid glands. It’s a prevalent endocrine disorder. Parathyroidectomy, the surgical excision of affected glands, stands as the definitive treatment, typically resulting in remission and normalization of calcium levels. However, persistent elevation of serum PTH post-parathyroidectomy ...

Introduction: Wilson’s disease is a rare and serious genetic disorder. The accumulation of copper in glands causes several endocrine pathologies. Herein, we report a rare case of hypophysitis with corticotropic deficiency caused by Wilson’s disease.Observation: A 33-years-old female patient was referred to the endocrinology department for hypoglycemia. She had a history of Wilson’s disease diagnosed at the age of nine complicated by cirrho...

Introduction: Isolated hypogonadotropic hypogonadism is a heterogeneous group of genetic abnormalities affecting the hypothalamic pituitary gonadal axis. The main mechanism consists of an impairment of the production or the action of gonadotropin releasing hormone (GnRH). While several mutations have been identified, the majority of cases remain without etiology. The objective of our study was to describe the clinical and biological profiles of these diseases.<p class="abs...

Introduction: Thyroid eye disease (TED) is an autoimmune inflammatory disorder affecting the orbital tissues. It occurs with thyroid dysfunction notably Graves’ disease. TED exhibits different severity patterns and has a lot of risk factors. We, herein, report a rare case of a severe TED developing after COVID-19 infection in a patient initially treated for hyperthyroidism without ocular manifestations.Observation: A 48-year-old female with a histor...

Introduction: Subclinical hyperthyroidism (SH) is defined by normal thyroid hormone levels and reduced thyroid-stimulating hormone (TSH) concentration. It still raises intriguing questions about its clinical impact, management and outcomes. The aim of our study was to determine the underlying etiologies of SH, its clinical features and its outcomes in Tunisian patients.Methods: We conducted a retrospective study at Charles Nicolle Hospital, including 46 ...

Introduction: Homeostasis of calcium and phosphor influence bone metabolism. They depend on several hormones, including parathyroid hormone, thyroid and sexual hormones. Low bone mass seems a common issue in endocrine disorders. The aim of this study is to identify the different endocrine disorders in patients with low bone mass.Methods: Retrospective study collecting the medical files of patients followed in the endocrinology department of Charles Nicol...

Introduction: Diabetes is a chronic, progressive disease characterized by elevated levels of blood glucose. In type 1 diabetes, some patients experience a “honeymoon period” shortly after diagnosis, wherein insulin needs decrease significantly and a few studies have demonstrated that drug-free glycemic control can be achieved in type 2 diabetes. We describe 2 unusual cases of endogenous hyperinsulinism and diabetes remission.Case presentation 1...

Introduction: Multiple endocrine neoplasia (MEN1) is a rare underdiagnosed inherited multi-tumor syndrome, affecting neuroendocrine and non-endocrine tissues. Its aspects are extremely variable with no genotype-phenotype correlation.Case report: A 57 year old woman with a history of hypertension, presented five months before her admission with asthenia, headache and vomiting, initial biological exams revealed a central hypothyroidism. A pituitary MRI sho...

Introduction: Since the hypothalamic-puituitary axis (HPA) is a radiosensitive region, cranial radiotherapy for head and neck malignancies represents a major risk factor for the development of endocrine complications particularly hypopituitarism.Case report: A 22 years old girl with a history of a undifferentiated carcinoma of nasopharyngeal type UCNT at the age of 09 years old treated with radiotherapy and chemotherapy was referred to the endocrinology ...